• Pain relief cream that actually works. Introducting Penetrex Advanced OTC Joint & Muscle Pain Relief Cream
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Over 2 million+ happy customers

Penetrex Advanced Joint & Muscle Pain Relief Cream, 2 oz with 5% Menthol

Penetrex Advanced Joint & Muscle Pain Relief Cream, 2 oz with 5% Menthol

 91,028 Reviews

Fast-acting OTC pain relief. 5% Menthol on top of the proven Penetrex formula 2 million+ people reorder. Built for the moment pain spikes. 100% money-back guarantee.

check_circle 5% Menthol — fast-acting OTC pain relief, in seconds. Higher concentration than competitors.

check_circle Absorbs in seconds. Leaves nothing behind.

check_circle 91,000+ five-star reviews — and 2 million+ units sold. Made in the USA 🇺🇸

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Pain relief cream that actually works. Introducting Penetrex Advanced OTC Joint & Muscle Pain Relief Cream

Penetrex Advanced Joint & Muscle Pain Relief Cream, 2 oz with 5% Menthol

 91,028 Reviews

About Penetrex:

5% Menthol is an OTC monograph active ingredient for the temporary relief of minor aches and pains of muscles and joints — including those associated with arthritis, simple backache, strains, sprains, and bruises. Apply it to the area that hurts. Within seconds, the cooling onset begins. That's not a sensation trick — that's the active ingredient working. Nothing enters your stomach. No GI irritation. No NSAIDs.

Most OTC pain creams stop at the active ingredient. We didn't. Penetrex Advanced gives you 5% Menthol — at a higher concentration than most competitors (3%) — plus the four-ingredient formula 2 million+ people already trust: Arnica for topical soothing, Vitamin B6 for skin health, MSM for area conditioning, and Boswellia Serrata for a calming experience. Five pathways. One cream. Made in the USA.

Apply it and the cooling onset hits within seconds. No greasy film. No white cast. No stained sheets or scrubs. The menthol scent is intentionally clean and subtle — nothing like the aggressive blast from old-school sports creams. Use it before work, before a meeting, or in bed. The sensation does its job. The smell doesn't announce it to the room.

Penetrex Advanced is built for the moments pain spikes — the morning your back won't cooperate, the 2am knee throb, the post-shift shoulder that needs relief now. Use it for the temporary relief of minor aches and pains of muscles and joints associated with arthritis, simple backache, strains, bruises, and sprains. For ongoing daily support, the same formula compounds with consistent use.

With a loyal customer base spanning over a decade, Penetrex has become a household name for natural topical support. Manufactured in the USA following strict quality standards, and suitable for those seeking vegan-friendly, paraben-free formulations.

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Most Pain Creams Fail At The Exact Moment You Need Them Most

5% Menthol for fast-acting OTC pain relief on contact. Plus the four-ingredient Penetrex formula working underneath — Arnica, Vitamin B6, MSM, and Boswellia. Five ingredients. One cream. Built for the moments pain spikes — and the days it doesn't let up.

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Fast-Acting OTC Pain Relief

5% Menthol — an OTC monograph active ingredient — temporarily relieves minor aches and pains of muscles and joints. Apply it, and within seconds the cooling onset begins.

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Absorbs in Seconds. Clean Scent.

No greasy film. No white cast. No stained sheets, scrubs, or sleeves. The menthol scent is intentionally subtle — nothing like the aggressive blast from old-school sports creams.

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Trusted by 2 Million+ Users

91,000+ five-star reviews. Over 2 million jars sold. Nurses, athletes, grandparents, people who've tried every cream on the shelf. They built the loyalty on the Penetrex formula. We added 5% Menthol on top.

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Five Ingredients. One Cream.

Most pain creams give you one active ingredient. Penetrex Advanced gives you five working together. 5% Menthol delivers fast-acting OTC pain relief.

 
 

Clinically backed ingredients

Feel It Working In Under A Minute.

The cooling onset hits in seconds. 5% Menthol temporarily relieves minor aches and pains of muscles and joints — including those associated with arthritis, simple backache, strains, bruises, and sprains. The four-ingredient Penetrex formula keeps working underneath. That's the difference between a sensation and an answer.

No pain, no gain? WRONG.

The Moment You Needed It Most — Just Got A Better Answer.

Morning stiffness before you can move. The 2am throb that wakes you up. The post-shift shoulder that won't let you sit down. That's exactly the moment most pain creams fail you. Penetrex Advanced was built for those moments — fast-acting OTC pain relief, with a real formula working underneath.

 
 

What's Inside & Why It Works

Select ingredients below to learn more

 

Menthol 5%

The OTC monograph active ingredient that makes Penetrex Advanced an OTC pain reliever. Menthol is a topical analgesic from the mint family, used for the temporary relief of minor aches and pains of muscles and joints associated with arthritis, simple backache, strains, sprains, and bruises.

Arnica is a great muscle relief ingredient

Arnica Montana

A botanical extract used for centuries in traditional topical applications. It targets the skin’s surface layers to provide a soothing sensation upon application.

Pyridoxine (Vitamin B6)

An essential nutrient incorporated into the formula to support skin health and complement the cream’s absorption process.

MSM / DMSO2 Methylsulfonylmethane

An organic sulfur compound frequently used in wellness formulations to support the targeted area’s overall condition.

Boswellia Serrata

A plant-derived resin known for its calming properties, working synergistically with the other ingredients for a comprehensive topical experience.

Most Pain Creams Stop At Menthol. We Didn't.

Every menthol cream on the shelf claims pain relief. Here's what's actually in each one.

  Others
5% Menthol (higher concentration than most competitors at 3%)
Five active ingredients targeting multiple pathways (Menthol 5%, Arnica, MSM, Vitamin B6 & Boswellia)
Fast-absorbing — no grease, no residue, no staining
Non-NSAID formula — nothing enters your stomach
Builds effectiveness with consistent daily use
91,000+ five-star reviews

Have Questions? We Have Answers.

Everything you need to know about common questions about our products and services.

  • Apply PENETREX® liberally to the affected area(s) and continue to massage in thoroughly for a minute or two until you can see that it has been absorbed through the skin. The appropriate amount of PENETREX® to use on each occasion should be enough so that the product massages in smoothly & comfortably over the entire area.

    Repeat this 3 to 4 times per day over an initial period of at least 7 to 10 days and thereafter on an as needed basis.

    As symptoms improve, reduce the frequency of applications accordingly to maintain relief and as a preventative measure. Many users have reported that over time PENETREX® provides them with more "efficient" results...requiring fewer applications while achieving quicker and more predictable results.

  • We have customers who call or e-mail us the next day after they start using PENETREX® and they express disbelief at how quickly it provided them with relief.

    At the same time, we also have customers who report back to us that they had begun to lose faith having used the product for a couple of weeks before they finally turned the corner.

  • We utilize Amazon Prime's shipping, so your item should be shipped within the next business day and arrive within 2-8 business days depending on your area.

  • With over 2 Million+ jars of PENETREX® having been distributed since it was introduced, there have been no reports of recurring incidents which would indicate a common occurrence of any negative reaction to the product.

    This is not surprising since all of the ingredients (see below) in PENETREX® are extremely well known and have been widely accepted by medical practitioners.

    PENETREX® Cream Ingredient List: Water (Aqua), Arnica Montana Flower Extract, Helianthus Annuus (Sunflower) Seed Oil, Glycerin, Glyceryl Stearate, PEG-100 Stearate, Cetyl Esters, Steareth-20, Pyridoxine Hydrochloride (Vitamin B6), Methylsulfonylmethane (MSM/DMSO2), Glucosamine (Vegetable Source), Bilineurine Bitartrate, Ethoxydiglycol, Methyl Gluceth-20, Cetyl Myristoleate, Aloe Barbadensis (Aloe Vera) Leaf Extract, Butyrospermum Parkii (Shea Butter), Boswellia Serrata (Frankincense) Oil, Mentha Piperita (Peppermint) Oil, Cinnamomum Camphora (Camphor), Melaleuca Alternifolia (Tea Tree) Leaf Oil, Tocopherol (Vitamin E), Dipotassium Glycyrrhizinate, Dimethicone, Ammonium Acryloyl-Dimethyltaurate/VP Copolymer, Phenoxyethanol, DMDM Hydantoin, Iodopropynyl Butylcarbamate

    PENETREX® Roll-On Gel Ingredient List: Water (Aqua), Isopropyl Alcohol, Arnica Montana Flower Extract, Pyridoxine Hydrochloride, Methylsulfonylmethane (MSM/DMSO2), Glucosamine (vegetable source), Bilineurine Bitartrate, Ethoxydiglycol, Cetyl Myristoleate, Aloe Barbadensis (Aloe Vera) Leaf Extract, Boswellia Serrata (Frankincense) Oil, Rosmarinus Officinalis (Rosemary) Oil, Juniperus Communis (Juniper Berry) Oil, Mentha Piperita (Peppermint) Oil, Eucalyptus Globulus (Eucalyptus) Leaf Oil, Melaleuca Alternifolia (Tee Tree) Leaf Oil, Cinnamomum Camphora (Camphor), Tocopherol (Vitamin E), Dipotassium Glycyrrhizinate, Carbomer, Triethanolamine, DMDM Hydantoin, Diazolidinyl Urea, Iodopropynyl Butylcarbamate

  • PENETREX® Cream Ingredient List: Water (Aqua), Arnica Montana Flower Extract, Helianthus Annuus (Sunflower) Seed Oil, Glycerin, Glyceryl Stearate, PEG-100 Stearate, Cetyl Esters, Steareth-20, Pyridoxine Hydrochloride (Vitamin B6), Methylsulfonylmethane (MSM/DMSO2), Glucosamine (Vegetable Source), Bilineurine Bitartrate, Ethoxydiglycol, Methyl Gluceth-20, Cetyl Myristoleate, Aloe Barbadensis (Aloe Vera) Leaf Extract, Butyrospermum Parkii (Shea Butter), Boswellia Serrata (Frankincense) Oil, Mentha Piperita (Peppermint) Oil, Cinnamomum Camphora (Camphor), Melaleuca Alternifolia (Tea Tree) Leaf Oil, Tocopherol (Vitamin E), Dipotassium Glycyrrhizinate, Dimethicone, Ammonium Acryloyl-Dimethyltaurate/VP Copolymer, Phenoxyethanol, DMDM Hydantoin, Iodopropynyl Butylcarbamate

    PENETREX® Roll-On Ingredient List: Water (Aqua), Isopropyl Alcohol, Arnica Montana Flower Extract, Pyridoxine Hydrochloride, Methylsulfonylmethane (MSM/DMSO2), Glucosamine (vegetable source), Bilineurine Bitartrate, Ethoxydiglycol, Cetyl Myristoleate, Aloe Barbadensis (Aloe Vera) Leaf Extract, Boswellia Serrata (Frankincense) Oil, Rosmarinus Officinalis (Rosemary) Oil, Juniperus Communis (Juniper Berry) Oil, Mentha Piperita (Peppermint) Oil, Eucalyptus Globulus (Eucalyptus) Leaf Oil, Melaleuca Alternifolia (Tee Tree) Leaf Oil, Cinnamomum Camphora (Camphor), Tocopherol (Vitamin E), Dipotassium Glycyrrhizinate, Carbomer, Triethanolamine, DMDM Hydantoin, Diazolidinyl Urea, Iodopropynyl Butylcarbamate 

  • Most customers find that using PENETREX® on its own as directed provides the benefits and relief they desire.

    Nevertheless, PENETREX® is currently being incorporated into overall therapy programs by end users as well as medical professionals worldwide who have found it to be an excellent compliment to other approaches including oral medications & prescriptions, orthopedic products, physical therapy and ultrasound.

    PENETREX® is a product that allows each individual to develop their own regimen that works best for them...on its own or as an invaluable member of a multi-faceted approach.

  • Absolutely Not. PENETREX® is lightly infused with a natural Chamomile Oil extract resulting in a pleasant yet hardly noticeable fragrance that vanishes completely after a minute or two.

    PENETREX® is Non-Greasy, Non-Staining, Paraben-Free, Made in the USA & NEVER Tested on Animals

  • PENETREX® was researched & developed by a renowned Chemist in Southern California.

    PENETREX® is available to people worldwide, exclusively through Biomax Health Products, Inc. of San Diego, California. You may order it here on www.penetrex.com, on Amazon.com or you may wish to use our handy Store Locator Tool to find a retailer near you. PENETREX® is now available in over 12,000 Retail Locations.

    With little to no advertising but strictly through word of mouth referrals and the Internet, Hundreds of Thousands of people from over 80 countries have been introduced to this product with great satisifaction.

    Ask your Doctor/Physical Therapist/Chiropractor, etc. if they are familiar with PENETREX®. If they are not and would like to learn more about the product, please feel free to have them contact us. We can answer any questions they may have about incorporating PENETREX® into their practice.

  • YES. Your PENETREX® Purchase & Complete Satisfaction is Unconditionally Guaranteed by Biomax Health Products, Inc.. If you are less than 100% Satisfied with PENETREX® for ANY reason, we sincerely urge you to take advantage of our "No-Hassle", "No Questions Asked", "No Time Limit", "No Fine Print" Refund Policy. Simply call our U.S. based Customer Service Team at (858) 356-5980 and your Refund will be processed quickly and respectfully...it's really that simple.

    PENETREX® is a very effective product which can be of immeasurable value to those who need it. The people who developed PENETREX® don’t want ANYONE who is suffering to miss out on discovering PENETREX® because of initial skepticism or fear of "buyer’s remorse".

  • Thanks to overwhelming demand, the 2-Ounce Jar of PENETREX® is now available in Walmart & CVS stores nationwide.

    Click here to find a store near you.